Introduction Cold Laser Therapy, also known as Low-Level Laser Therapy (LLLT), has gained substantial attention in clinical settings for its non-invasive approach to pain relief and tissue repair. In acute inflammation phases, such as post-injury joint swelling, tendon irritation, or sports-related trauma, healthcare providers frequently face a critical question: is Cold Laser Therapy safe and effective during this stage? This article explores the scientific rationale, clinical evidence, benefits, risks, and practical recommendations for employing Cold Laser Therapy during acute inflammatory conditions, particularly in musculoskeletal contexts. Understanding these details helps clinicians and patients make informed decisions while optimizing treatment outcomes. 1. What is Cold Laser Therapy? Cold Laser Therapy has been widely used in rehabilitation medicine and physical therapy to facilitate cellular repair and pain reduction. Before evaluating its application during acute ...